Integrins in Health and Disease: Key Effectors of Cell-Matrix

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Integrins in Health and Disease: Key Effectors of Cell-Matrix

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Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis..